Once the vacation spot of the likes of Frank Sinatra and Elvis Presley, Palm Springs continues to be the oasis of the Coachella Valley. With 300 days of sunshine, a myriad of outdoor activities, and fun nightlife, it is the desert getaway you've been dreaming of.
If time is of the essence, the fastest route from San Francisco is definitely Interstate 5 South. This route will get you to Palm Springs in 7 hours and is fairly direct. However, because it takes you through flat farmland, you will not get much in terms of scenery. For one of the most scenic routes in the world, drive down the coast. Take Highway 1 to Highway 101, and eventually to Interstate 10. This gorgeous drive will take you through the Big Sur, and beautiful coastal towns like Santa Barbara and San Luis Obispo, where you can stop to rest and enjoy some delicious lunch. You can also make a stop at the Point Lobos State National Reserve or the Julia Pfeiffer Burns State Park- both of which offer some of the most astonishing views of the coast.